Harmine & Harmaline

Harmala Alkaloids of Ayahuasca

Harmala earrings & pendant 

Harmine, also known as telepathine, is a fluorescent harmala alkaloid belonging to the betacarboline family of compounds.Found in the vine Banisteriopsis caapi known as “ayahuasca” Harmine reversibly inhibits monoamine oxidase A , therefore it is a MAO Inhibitor (MAOI)

Monoamines include neurotransmitters (serotonin, dopamine), hormones (melatonin,epinephrine, norepinephrine) and psychedelic drugs (psilocybin, DMT and mescaline). Byslowing the breakdown of neurotransmitters, monoamine oxidase inhibitors (MAOIs) can help to replenish the body’s supply of these chemicals, and many MAOI’s are used as antidepressants.

Harmine is an indole alkaloid with the indole ring structure that is characteristic of the β-carboline alkaloids. The β-carboline alkaloids include harmine, harmaline, harman and harmalol,

Biosynthesized through the combination of five and six-membered ring structures that arederived from the amino acid’s either L-tryptophan or tryptamine- which facilitates the formation of an indole ring system

These alkaloids are of interest for their use in Amazonian shamanism, The harmala alkaloid harmine, once known as telepathine, is a naturally occurring beta-carboline alkaloid that is structurally related to harmaline, and also found in the vine Banisteriopsis caapi.

Banisteriopsi caapi is traditionally used in the preparation of Ayahuasca B. caapi has a tradition of use in conjunction with plants such as Chacruna containing DMT. Traditionally, B. caapi is consumed as a drink, with or without the DMT-bearing plants. Ordinarily, DMT is not active when taken orally, except when MAOIs are present in such beverages.